Our main research interests are focused on the dynamics of cancer mobility and tumor invasion, the mechanism of tumorigenesis and development, et al.
1.Mechanism of tumor cell invasion and migration;
2.Mechanism and function of cancer stem cell in brain cancer development and progression.
3.Regulation of tumor microenvironment (TME) in tumorigenesis and progression.
Email: z.fang@cmpt.ac.cn
1. Chen X, Zhang S, Wang Z, Wang F, Cao X, Wu Q, Zhao C, Ma H, Ye F, Wang H, Fang Z(#). Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway. J Exp Clin Cancer Res. 2018 Jun 28;37(1):128
2. Chen X(#), Wang Z, Ma H, Zhang S, Yang H, Wang H, Fang Z (#). Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma. Oncotarget, 2017, 24;8(55):93580-93592
3. Chen X(#), Ma H, Wang Z, Zhang S, Yang H, Fang Z(#). EZH2 palmitoylation mediated by ZDHHC5 in p53 mutant glioma drives malignant development and progression. Cancer Res. 2017, 15;77(18):4998-5010. (#: corresponding author)
4. Chen X(#), Hao A, Li X, Du Z, Li H, Wang H, Yang H, Fang Z(#). Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis. J Pineal Res. 2016, 61(2):208~217
5. Fang Z(#) , Luna EJ(#). Supervillin-mediated suppression of p53 protein enhances cell survival. Journal of Biological Chemistry. 2013.3.15, 288 (11):7918~7929
6. Fang Z , Takizawa N, Wilson KA, Smith TC, Delprato A, Davidson MW, Lambright DG, Luna EJ. The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic, 2010.6.01, 11(6) : 782~799
Fang Z, Miao Y, Ding X, Deng H, Liu S, Wang F, Zhou R, Watson C, Fu C, Hu Q, Lillard W Jr, Powell M, Chen Y, Forte JG, Yao X. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. Molecular & Cellular Proteomics. 2006.8.01, 5(8):1437~1449